Initial signals of efficacy in cholangiocarcinoma from a phase Ib trial of varlitinib in combination with doublet chemotherapy (cisplatin + 5-fluororacil or capecitabine).
C.Y. Hsieh, M.S. Wu, M. McHale, B. Lindmark, L. Chow, Y. Chao.
ASCO (2017), Abstract Number e15671.

Pan-HER inhibitor, varlitinib (ASLAN001) disrupts HER/ERK signaling and causes apoptosis in triple negative breast cancer cells.
C.Y. Liu, T.T. Huang, C.T. Huang,  H.P. Yang, L.M. Tseng, C.W. Shiau, K.F. Chen.
AACR (2017), Abstract Number 2087.

Varlitinib to demonstrate anti-tumour efficacy in patient-derived hepatocellular carcinoma xenograft models.
C.Y. Hsieh, L. Ooi, R. Ong, B. Lindmark, M. McHale, H.T. Huynh.
ASCO (2016), Abstract Number e15598.

Varlitinib demonstrates potent antitumour efficacy in patient-derived gastric cancer xenograft models.
H.T. Huynh, R. Ong, B. Lindmark, M. McHale, A.G.L. Ooi.
AACR (2016), Abstract Number 4719.

Phase IIA study to evaluate the biological activity of ASLAN001 in HER-1/2 co-expressing or HER-2 amplified advanced gastric cancer.
J. Kim, S. Im, K. Lee, J.W. Kim, K. Lee, S. Han, T. Kim, I.S. Choi, D. Oh, N. Lee, C. Song, M. Foster, M. McHale, A. Barge, W.H. Kim, Y. Bang
ESMO (2014), Abstract Number 664P.

RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis.
Andrade, J. Fornetti, L. Zhao, S.C. Miller, R.L. Randall, N. Anderson, S.E. Waltz, M. McHale, A.L. Welm.
Science Translational Medicine (2017), 9(374), eaai9338.

Pre-clinical efficacy of RON kinase inhibitors alone and in combination with PI3K inhibitors for treatment of sfRon-expressing breast cancer patient-derived xenografts.
M. Bieniasz, P. Radhakrishnan, N. Faham, J-P. De La O, A. L. Welm.
Clinical Cancer Research (2015), 21 (16); doi: 10.1158/1078-0432.CCR-14-3283  

Inhibition of Ron Kinase Blocks Conversion of Micrometastases to Overt Metastases by Boosting Antitumor Immunity.
H. Eyob, H.A. Ekiz, Y.S. DeRose, S.E. Waltz, M.A. Williams, A.L. Welm
Cancer Discovery 2013, 3, 751-760.

RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses.
H. Eyob, H.A. Ekiz, A.L. Welm
Oncoimmunology (2013), 2(9), e25670.

RON’s new role.
C. Cain
SciBX 6(21); doi: 10.1038/scibx.2013.507

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