ASLAN003, a Novel and Potent Dihydroorotate Dehydrogenase (DHODH) Inhibitor, Induces Differentiation of Acute Myeloid Leukemia
J. Zhou, J.Y. Quah, J.Y. Chooi, S.H. Toh, B. Lin, M. Osato, Q. Seet, L. Ooi, B. Lindmark, M. McHale, W.J. Chng
ASH (2018), Poster number: 4047

Preliminary Results of a Phase 2a Dose Optimization Study of ASLAN003 (DHODH inhibitor) in Acute Myeloid Leukemia (AML) Patients Who Are Ineligible for Standard Therapy; Early Signs of Activity
S.B. Ting, C.H. Ng, A. Bajel, W.Y.K. Hwang, H.J. Shih, W.J. Chng, M. McHale, C.Y. Hsieh, H.J. Shih, N. McIntyre, J. Kwek , W.L. Chang, B. Lindmark.
ASH (2018), Poster number: 2676

A phase IIa dose optimization study of ASLAN003 in Acute Myeloid Leukemia (AML)
C.H. Ng, S.B. Ting, W.Y.K. Hwang, A. Bajel, R. Eek, M. McHale, H.-J. Shih, N. McIntyre, J. Kwek , B. Lindmark.
ESMO (2018), Abstract number: 1043TiP

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Multicenter open label, randomized Phase 2 trial of varlitinib versus lapatinib in combination with capecitabine in patients with HER2+ metastatic breast cancer (MBC) who failed prior trastuzumab therapy
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Initial signals of efficacy in cholangiocarcinoma from a phase Ib trial of varlitinib in combination with doublet chemotherapy (cisplatin + 5-fluororacil or capecitabine).
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Pan-HER inhibitor, varlitinib (ASLAN001) disrupts HER/ERK signaling and causes apoptosis in triple negative breast cancer cells.
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Varlitinib to demonstrate anti-tumour efficacy in patient-derived hepatocellular carcinoma xenograft models.
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Varlitinib demonstrates potent antitumour efficacy in patient-derived gastric cancer xenograft models.
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Phase IIA study to evaluate the biological activity of varlitinib (ASLAN001) in HER-1/2 co-expressing or HER-2 amplified advanced gastric cancer.
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Pan-ErbB inhibition by varlitinib (ARRY-334543) is superior to selective ErbB inhibition in a preclinical model that signals through multiple ErbB receptors.
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AACR (2010), Abstract Number 3610.

In vivo activity of varlitinib (ARRY-334543), a potent, small molecule inhibitor of EGFR/ErbB-2 in combination with trastuzumab, capecitabine or docetaxel.
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AACR (2009), Abstract Number 1757

Differential activity of varlitinib (ARRY-543), a potent, small molecule inhibitor of EGFR/ErbB2 compared to lapatinib in in vivo xenograft models.
K.Bouhana, T. Pheneger, R. Woessner, G. Tarlton, I.V. Carlowitz, K. Hoffman, E. Wallace, K. Koch, J. Winkler, S. Winski, P. Lee.
AACR (2008). Abstract Number 4848.

In vivo activity of varlitinib (ARRY-334543), a potent, small molecule inhibitor of EGFR/ErbB-2 in combination with trastuzumab or docetaxel.
P.Lee, D. Anderson, A. Avrutskaya, A. White, T. Pheneger, J. Winkler.
CTRC-AACR San Antonio Breast Cancer Symposium (2008). Abstract Number 2150.

In vivo anti-tumour activity of varlitinib (ARRY-334543), a small molecule inhibitor of EGFR and ErbB-2.
T.Pheneger, R. Woessner, S. Winski, D. Anderson, J. Lyssikatos, B. Bernat, G. Miknis, G. Topalov, L. Ren, E. Wallace, P. Lee.
AACR-NCI-EORTC (2005). Abstract Number A247.

Varlitinib (ARRY-334543), a potent, orally active small molecule inhibitor of EGFR and ErbB-2.
G.Miknis, E. Wallace, J. Lyssikatos, P. Lee, Q. Zhao, J. Hans, G. Topalov, A. Buckmelter, G. Tarlton, L. Ren, J. Tullis, B. Bernat, L.P. Opie, I.V. Carlowitz, J. Parry, T. Morales, M. Perrier, R. Woessner, T. Pheneger, K. Hoffman, J. Winkler, K. Koch.
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RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis.
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