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We believe ASLAN003 has the potential to be the most potent oral inhibitor of DHODH currently in development for autoimmune disease. ASLAN003 is a highly selective and potent inhibitor of human DHODH (IC50 = 35 nM) and has been shown to be more than 30 times more potent at inhibiting the DHODH enzyme in cell free and cell-based assays than the first generation inhibitor teriflunomide. In preclinical studies, ASLAN003 was shown to be efficacious in animal models of MS and other autoimmune diseases. Based on the specificity, potency and favourable safety profile identified in earlier clinical studies, ASLAN believes ASLAN003 is a promising candidate for development in these diseases, where a pressing need for differentiated and convenient treatment options exists.
ASLAN has previously observed anti-viral activity of ASLAN003 against Dengue and Zika viruses and recently determined that ASLAN003 has nanomolar potency against SARS-CoV-2 in Vero E6 cells (EC50 = 1.4 nM). ASLAN is currently assessing the potential of ASLAN003 as a treatment for COVID-19 and other viral infections and will provide an update when clinical development plans have been determined.
In 2019, ASLAN completed a Phase 2 study testing ASLAN003 in AML. Following an internal strategic review and noting changes in the AML treatment landscape, ASLAN will be focusing the future development of ASLAN003 in autoimmune disease.
ASLAN has partnered with Almirall for the development of ASLAN003. Almirall is a leading skin-health focused global pharmaceutical company that partners with healthcare professionals, applying Science to provide medical solutions to patients and future generations. The company, founded in 1943 and with headquarters in Barcelona, is listed on the Spanish Stock Exchange (ticker: ALM).
To learn more about Almirall, please visit www.almirall.com
ASLAN has partnered with BioGenetics for the commercialisation of varlitinib and ASLAN003 in South Korea. BioGenetics, formerly Unidus Corporation, is a Korea-based company established in 1973 engaged in the manufacturing of medical products. As part of the company’s diversification strategy, BioGenetics established its biopharmaceutical division in April 2018 and appointed Mr Joohoon Ahn, as CEO of the newly established division. Mr Ahn was most recently Senior Managing Director at Kwangdong Pharmaceuticals, one of the top 3 domestic pharmaceutical companies in Korea, and has 28 years of experience in the Korean pharma industry in regulatory affairs, commercialisation, and business development. Biogenetics is co-developing WM-S1-001 for Erbitux®-resistant colon cancer with WellMarkerBio, a spin-off company from Asan Medical Center, one of the largest private hospitals in Korea.