Initial signals of efficacy in cholangiocarcinoma from a phase Ib trial of varlitinib in combination with doublet chemotherapy (cisplatin + 5-fluororacil or capecitabine).
C.Y. Hsieh, M.S. Wu, M. McHale, B. Lindmark, L. Chow, Y. Chao.
ASCO (2017), Abstract Number e15671.
Pan-HER inhibitor, varlitinib (ASLAN001) disrupts HER/ERK signaling and causes apoptosis in triple negative breast cancer cells.
C.Y. Liu, T.T. Huang, C.T. Huang, H.P. Yang, L.M. Tseng, C.W. Shiau, K.F. Chen.
AACR (2017), Abstract Number 2087.
Varlitinib to demonstrate anti-tumour efficacy in patient-derived hepatocellular carcinoma xenograft models.
C.Y. Hsieh, L. Ooi, R. Ong, B. Lindmark, M. McHale, H.T. Huynh.
ASCO (2016), Abstract Number e15598.
Varlitinib demonstrates potent antitumour efficacy in patient-derived gastric cancer xenograft models.
H.T. Huynh, R. Ong, B. Lindmark, M. McHale, A.G.L. Ooi.
AACR (2016), Abstract Number 4719.
Phase IIA study to evaluate the biological activity of ASLAN001 in HER-1/2 co-expressing or HER-2 amplified advanced gastric cancer.
J. Kim, S. Im, K. Lee, J.W. Kim, K. Lee, S. Han, T. Kim, I.S. Choi, D. Oh, N. Lee, C. Song, M. Foster, M. McHale, A. Barge, W.H. Kim, Y. Bang
ESMO (2014), Abstract Number 664P.